While semaglutide is highly effective for weight loss, metformin has modest weight-reducing effects, primarily through its role in stimulating the production of N-lactoyl-phenylalanine, an appetite-suppressing metabolite generated in the intestine 61
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[DOI] [PubMed] [Google Scholar] 61.Sukuki N., Koussevitzky S., Mittler R., Miller G
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That is at odds with a much larger systematic review published in The BMJ, formerly known as the British Medical Journal