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Additionally, iron plays a significant role in this process, as it catalyzes reactions that generate oxidative stress

Tremendous progress has been made in understanding its pathophysiology and pathobiological complexities, but developing treatments, has been disproportionately slow and elusive

2011, doi: 10.1016/j.archger.2010.10.004

The a-carboxyl group of the resulting g-Glu-Cys is then joined in a normal peptide bond with the a-amino group of glycine, catalyzed by glutathione synthetase

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