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For some users, it manifests as a persistent mild queasiness

So, the number of subjects in each arm of the study was relatively small compared to a proper phase III study, where we usually go for numbers anywhere upwards from 1,500

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Fluid retention occurred in 32% of women with axillary node-negative, estrogen-receptor positive breast cancer who received adjuvant tamoxifen (n = 1422) compared with 30% of women who received placebo (n = 1437) following primary surgery in a randomized, double-blind study (the NSABP B-14 study)