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Functionally diversified BiP orthologs control body growth, reproduction, stress resistance, aging, and ER-phagy in Caenorhabditis elegans

The modern diet, which typically contains up to 15 times more omega-6 PUFAs than omega-3 PUFAs, along with a common deficiency of DHA in the brain, results in the production of large amounts of lipid mediators derived from LA and AA, contributing to chronic inflammation and oxidative stress implicated in cardiovascular, metabolic, inflammatory, and neuropsychiatric disorders (18, 50, 5759)

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More frequently, such strategies have led to the overexpression of structural and regulatory genes involved in the synthesis of riboflavin or that of its precursors

Together, these peptides may aid in bone and cartilage repair