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The LR3 modification makes the molecule resist the binding proteins that normally clear native IGF-1 from circulation quickly

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Considering the importance of the model in studying drugs metabolism, further study of it is also of great significance for the development and improvement of future metabolic models

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This article gives an outline of the increasing amount of peptides that have been implicated in energy homeostasis and appetite regulation and describes the putative roles of most of the currently known participants

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