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Most available information comes from clinical trial protocols that don't translate easily to real-world use

Before starting B12 supplements , particularly high-dose formulations, discuss with your GP if you have: A history of sleep disorders Existing anxiety or mood disorders Cardiovascular conditions Kidney disease (which may affect B12 metabolism and test interpretation) Leber's hereditary optic neuropathy (cyanocobalamin is contraindicated

The mechanisms are fundamentally different: steroids suppress inflammation temporarily, while peptides aim to modulate inflammation while promoting regeneration

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