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Similarly, when vitamin B12 forms are given to deficient patients and interact with biological agents such as nicotinamide adenine dinucleotide phosphate, flavin mononucleotide, or flavin adenine dinucleotide, the Co-C and Co-O bonds break, and the central cobalt atom is reduced by one electron, with similar effects

The significant sequence homology has important implications for IGF-1R function in general, and oncogenesis in particular

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