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Moreover, we found that colistin-induced depolarization is sensitive to cyclosporin A, a potent inhibitor of mitochondrial cyclophilin D (CyPD), one of the components of the mPTP, whose expression and function are required for the onset of the permeability transition 49

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It currently is not indicated for any indications outside of that particular use

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(Off-label use means a drug is prescribed for a purpose other than what its approved to treat or help prevent.) If you have bothersome side effects, your doctor may adjust your dosage or recommend switching to a different medication

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