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The design logic is that skin and connective-tissue outcomes are rarely limited by one pathway

Full discussion is in paper3

That is a metabolic-rate mechanism, not an appetite-suppression mechanism like Semaglutide or Tirzepatide

thanks the support from Guangdong Innovative Research Team Program of China (201101C0105067115)

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Treatment with methionine was stopped, betaine was continued with 250 mg/kg PO and folic acid with 10 mg PO per day