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It is classified under WADA's S0 (Unapproved Substances) category and is prohibited in competitive sport regardless of administration route

Skin flares, joint pain, fatigue, recurrent mouth ulcers, histamine-type reactions, and autoimmune concerns may also require a broader workup

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A 2025 review in Endocrinology found that endogenous sex hormones estrogen in particular modulate GLP-1 receptor expression in the hypothalamus, and that women experience both greater weight loss and higher rates of side effects than men on GLP-1 agonists