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Of note, our previous work demonstrated that the gut metabolite NaB markedly reversed HFD-induced dysbiosis of the gut microbiota in mice and significantly elevated the abundance of Lactobacilli in the gut 10 , which supported the hypothesis that NaB might have the potential to improve GLP-1 resistance

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Cagrilintide is a long-acting synthetic analogue of the pancreatic hormone amylin, engineered with a fatty-acid side chain that extends its plasma half-life relative to native amylin