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Lastly, the wider CrIs in the NMA compared with the CI in SURMOUNT-5 may be explained by the use of a Bayesian analysis with random effect for the NMA, resulting in greater uncertainty in the results introduced by the heterogeneity of multiple trials per treatment comparison in the NMA

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We have reduced our fullyear outlook due to lowerthanplanned branded GLP1 penetration, which is impacted by the rapid expansion of compounding in the U.S. Former Novo CEO Lars Jrgensen, May 2025 The FDA ended the semaglutide shortage exemption soon after

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