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10.1038/s41586-022-04828-5 81 LiX.KangX.DiY.SunS.YangL.WangB.et al (2023)

Placebo (FOURIER trial, N=27,564) Monitoring recommended / fasting lipid panel every 4 to 12 weeks after initiation Prescriber disclosure / always required for any new supplement How Repatha (Evolocumab) Works and Why Metabolism Matters Evolocumab is a fully human IgG2 monoclonal antibody that binds proprotein convertase subtilisin/kexin type 9 (PCSK9), blocking PCSK9 from degrading LDL receptors on hepatocytes

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Nutrient-rich eating: Focus on vegetables, fruits, lean protein, and whole grains

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