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Key Takeaways GLP-1 medications can help with weight loss on their own, but workouts add benefits that go beyond what the medication can deliver Strength training helps you hold onto more lean mass and strength as you lose weight, which supports how your body looks, feels, and performs during the process A realistic baseline of two strength sessions per week can build momentum, and you can layer in cardio like walking, cycling, swimming, or classes as your energy and schedule allow Though GLP-1 medications can help people lose weight without exercise, its best to stick to a workout plan while you take them
For instance, in preclinical models, long-term ketamine exposure increases the expression of GABA receptor subunits in the prefrontal cortex while simultaneously reducing glutamate receptor subunits, impairing synaptic signaling and cognitive function ( Ketamine also downregulates brain-derived neurotrophic factor, particularly in the hippocampus, exacerbating deficits in synaptic plasticity and cognitive functions
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The bottom line There are lots of positive health benefits from using a GLP-1 to eat less and lose weight, but there are also a few challenges, especially losing bone density and muscle mass
You answer six quick questions about your weight loss goals, current weight, target weight, and basic health status
