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Replacement of GLP-2R ECL1 by poly-alanine abolished the ability of GLP-2 to elicit cAMP response, while replacement by that of GLP-1R diminished its potency by 196-fold

Whether cagrilintide dosage with retatrutide specifically emerges as a validated approach remains to be seen

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[ix] This finding means there are new and promising ways to help treat diseases that affect the brain and nerves