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Days 1-2 bring the most intense redness and sensitivity

Lead Researcher Spotlight Professor Ania M

The most commonly reported adverse events were gastrointestinal

The science of slowed gastrointestinal motility GLP-1 receptor agonists act on the gutbrain axis and are known to slow gastric emptying and overall gastrointestinal transit , contributing to early satiety and appetite suppression. As intestinal transit slows, the colon has more time to absorb water from stool , leading to hard, dry stools that are difficult to pass . Constipation is a common, dose-related adverse effect listed in FDA prescribing information for both Wegovy (semaglutide) and Zepbound (tirzepatide) and is most frequently reported during dose escalation , with improvement over time., Step-by-Step MD Protocol for Relief 1

Conclusion The feasibility and patient acceptability of this personalized, web-based approach to defining meaningful change will be evaluated comprehensively upon completion of both baseline and 6-week assessments

Mann is a diplomate of the American Board of Obesity Medicine and a certified menopause practitioner (MSCP) through The Menopause Society