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Additionally, ERAD dysfunction can disrupt lipid metabolism and cholesterol synthesis by impairing the degradation of SREBPs, further exacerbating cardiovascular disease

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This dual-delivery strategy effectively co-localized antiPD-1 antibodies and curcumin within tumors and demonstrated superior therapeutic efficacy in both in vitro and in vivo models (155).Collectively, these technological advances highlight nanotechnology-based delivery as a critical and clinically relevant strategy to bridge the gap between the promising immunometabolic activities of natural products and their successful translation into cancer immunotherapy

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