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Because of these differences, direct dose conversion is not medically appropriate

If they're over 65 kg, then adult guidelines should be followed

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I also observed a worsening of pre-existing POTS symptoms a condition that, in hypermobile Ehlers-Danlos Syndrome, is not incidental but mechanistically downstream: a recognized consequence of defective extracellular matrix that can produce peripheral venous laxity, impaired lower-extremity vasoconstriction, chronic hypovolemia, and the compensatory hyperadrenergic state that characterizes the neuropathic POTS phenotype

Results Timeline| recommended sessions: Which conditions can be treated with it