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High-dose vitamin B12 supplements taken concurrently with the injection may lead to excessive B12 levels, though toxicity from vitamin B12 excess is extremely rare due to its water-soluble nature and efficient renal excretion
(PubMed) Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen RH, Stabler SP
When vitamin B12 levels are low, a person can develop health problems related to red blood cells and nerve cells malfunctioning