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68 However, in a population using GLP-1 RAs for obesity management without history of diabetes, increased risk of pancreatitis associated with the GLP-1 RAs was found compared to bupropion-naltrexone (HR 9.1, 95%CI 1.2566.0) suggesting the risk benefit ratio of these medications is influenced by underlying disease state

This suppression results in a reduction in the levels of non-enzymatic antioxidants and a decline in the activities of antioxidant enzymes, thereby facilitating the accumulation of reactive oxygen species (ROS)

ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function