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Signs You Might Have an MTHFR Mutation: History of anxiety or depression Migraines Hormonal imbalances or fertility issues Poor detoxification (sensitivity to chemicals, alcohol, or strong smells) Chronic fatigue or fibromyalgia Trouble tolerating synthetic vitamins or medications People with an MTHFR mutation may struggle to properly use synthetic forms of nutrients, which makes choosing the right kind of B12 and folate essential