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Son M, Park IS, Kim S et al (2022) Novel potassium-competitive acid blocker, tegoprazan, protects against colitis by improving gut barrier function

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However, the NADPH-oxidase activity (which also uses NADPH as a cofactor) is increased (producing H 2 O 2 ) during active vitiligo, therefore increasing ROS and promoting an active competition with EAS enzymes for NADPH molecules, a molecule already reduced in active vitiligo patients (Shajil and Begum, 2006)

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Catabolism of -Amino--Carboxymuconate--Semialdehyde: ACMS The -amino--carboxymuconate--semialdehyde (ACMS: 2-amino-3-carboxymuconate-6-semialdehyde) product of the HAAO catalyzed reaction is ultimately catabolized to acetoacetyl-CoA