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The metabolic derangements incorporate PDHC and TCA cycle defects: increased blood lactate and pyruvate, elevated plasma alanine, BCAA, presence of allo-isoleucine in plasma, and increased urinary lactic, pyruvic, 2-ketoglutaric, and branched-chain 2-hydroxy- and 2-ketoacid [143,144]

E.FrisinaM

PLoS One 2014

Type 2 diabetes management : FDA-approved doses are calibrated for glycemic control

Najafi M, Shirazi A, Motevaseli E, Geraily Gh, Norouzi F, Heidari M, Rezapoor S

Because these variables move independently of one another, two vials with identical labels may require different handling depending on how the resulting solution will be used