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GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]
Benzethonium Chloride: A Novel Anticancer Agent Identified by Using a Cell-Based Small-Molecule Screen
They support your bodys ability to adapt to daily stressors and maintain equilibrium, and in doing so adaptogens are shown to increase your stress resilience, and help balance your hormones, and support your mood
Cancer Res (2005) 65:8896904
& Mohammadi, M
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