The oral diabetes medication canagliflozin (Invokana) is also based on this mechanism (Sarnoski-Brocavich 2013
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This can lead to the development of specific antibodies that neutralize the drug or cause allergic reactions, potentially resulting in serious complications for patients
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Some cheaper supplements use the oxidized form, which the body has to work harder to convert, further reducing efficiency
While these responses are adaptive in the short term, prolonged exposure to high cortisol levels and chronic stress can lead to maladaptive outcomes such as immunosuppression, impaired growth, altered behaviour, and oxidative damage, leading to increased disease susceptibility and reduced performance [19, 83]