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Understanding GLP-1R agonists Mechanism of action GLP-1R agonists mimic the hormone GLP-1 , which regulates: Insulin secretion (increases insulin release in response to glucose)

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Likewise, HDL quality is more important than apoA-I levels, which also do not correlate with HDL function, e.g

And it's not just a concern about side effects that we want to take these pleiotropic effects into consideration