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While both are highly effective at lowering insulin resistance, many endocrinologists find that Mounjaro provides slightly better overall weight loss and blood sugar control because it targets two distinct metabolic hormones rather than just one

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While safety data is encouraging, with no significant differences in adverse events compared to placebo, a larger Phase IV outcomes trial is ongoing to confirm the long-term cardiovascular benefits of enlicitide, and Merck has initiated the FDA approval process, with the drug in the fast track program