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Current avenues of research include randomized trials in assisted reproduction contexts, dose-finding investigations, and biomarker efforts to connect antioxidant and matrix changes to the success of embryo implantation

There is not enough safety data on topical GHK-Cu for pregnant or nursing individuals

Do not use in case of hypersensitivity to any of the components of the preparation

doi: 10.1172/JCI28111 148 KomaravelliN.CasolaA

Rafael Franco, all the Associate Editors, Editorial Board members, and Guest Editors mentioned above had no involvement in the decision-making or the review process of this manuscript

This has been reconsidered recently with a systematic analysis of a more limited set of agonists using the operational model to define operational efficacy for a range of end-points that reflect G protein activation or arrestin translocation (Rivero et al., 2012)