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In one trial, artichoke extract (1,800 mg/day) for six weeks reduced total cholesterol (-9.9%) and LDL cholesterol (-16.6%) in 71 hypercholesterolemic patients, with no differences in HDL cholesterol or triglycerides

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In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision