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doi: 10.1016/j.phrs.2019.01.019 54 FreemanW

Metformin remains the first-line agent recommended by NICE NG28, typically achieving HbA1c reductions of 1.01.5% (1116 mmol/mol), making it more potent than gliptins as a standalone treatment

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Regular monitoring of renal function, HbA1c, and body weight is recommended, with treatment adjustments made according to clinical response and tolerability

56 weeks old) were group housed and acclimatized for 34 days with ad libitum access to normal chow prior to the study