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Data Animal Data Developmental and reproductive toxicity studies with SYMLIN were performed in pregnant rats and rabbits

Rodent behavioural paradigms (such as Morris water maze or novel object recognition) provide complementary in vivo endpoints for studying cognitive function-related signalling research questions.

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11 Combined therapy from long-term, controlled clinical trials is highly needed

EMA = European Medicines Agency

Study findings Publication title, abstract, and full-text screening revealed only 12 clinical trials (seven randomized controlled trials [RCTs]) and 10 observational studies fitting inclusion criteria