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Nevertheless, given the increasingly established role of ROS in inducing sperm DNA damage, male infertility, and poor pregnancy outcomes, understanding risk factors for increased germline oxidative stress can inform improved clinical management strategies for men infertility and their families (86)

And oral HRT is one of the most commonly prescribed hormone delivery methods

in vitro experiments, metformin did not directly inhibit DPP4 activity (Hinke et al., 2002)

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