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All this means that there are differences between these compounds in terms of their potency in reducing HbA1c, baseline glycemia or weight reduction, among other factors, which should be considered when choosing drugs from this family.78,83,84 Cardiovascular protection of glucagon-like peptide type 1 receptor agonists Several randomized clinical trials have analyzed the cardiovascular safety of arGLP1 versus standard therapy

CagriSema, as of mid-2026, has completed its Phase 3a REDEFINE program but is not approved by the FDA, the EMA, or any other regulator, and its benefitrisk profile is still under review

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Journal of Neuroscience Research 86 (2): 326-38