Ferroptosis scoring for CD8+ T cells and subsequent cell communication analysis revealed stronger interactions between CD8+ T cells with higher ferroptosis scores and other immune cells through IFN-II and CCL signaling, further intensifying the activation of the inflammatory microenvironment
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237,238 Synphilin-1 also significantly decreases p53 expression and transcriptional activity and reduces p53 mRNA levels and p53 promoter transactivation, which are caused mainly by the production of C-terminal products through caspase-3-mediated cleavage
