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Finally, 0.5 mg of larazotide t.i.d., but not the higher doses, improved symptoms in CeD patients with persistent symptoms despite following a gluten-free diet (99)

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The first and rate-limiting step, catalyzed by glutamate-cysteine ligase (GCL), generates -glutamylcysteine from glutamate and cysteine

Safety monitoring, which Frank said was most important of all