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Risk factors for hemorrhage include the use of NSAIDs, lack of dietary fiber, constipation, and advancing age.10-12 Bleeding usually ceases spontaneously, with less than 1% of patients requiring greater than 4 units of blood.9 However, bleeding can become more hemodynamically significant in elderly patients with comorbid conditions, such as cerebrovascular disease or atherosclerotic cardiovascular disease, and in those with polypharmacy who may be taking anticoagulants or NSAIDs
Moreover, age also influences the loss of GSH, even in healthy individuals, yet antioxidant defenses decrease [133]
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Novo Nordisks Canadian patent didnt expire on schedule
