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Plasma free fatty acid (FFA) concentrations were measured using the Free Fatty Acid Quantification Kit (Sigma-Aldrich) in separate cohorts of mice, including both sexes of whole-body Gpr146/ and Gpr146/ mice on HFD, as well as adipose-specific and liver-specific knockout models following HFD feeding

Figure 8 illustrates the fate of dietary polyphenols within the human digestive system, beginning with their natural occurrence in fruits and vegetables as aglycones, glycosides, or bound forms

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Despite the promising findings reported in preclinical studies, it is important to emphasize that the majority of the available evidence originates from animal models and cell culture experiments

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