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This analysis indicates that in individuals with type 2 diabetes and high cardiovascular risk, tirzepatide may effectively mitigate the decline in eGFR and reduce UACR more effectively than insulin glargine

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GLP-1 RAs slow gastric emptying through vagal and central nervous system pathways, leading to retained stomach contents despite standard fasting [6,7,8]

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Patients with certain kidney conditions, heart failure, or active cardiovascular instability may require modified formulas or additional evaluation before treatment