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t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

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AOD-9604 (Anti-Obesity Drug 9604) is a synthetic hexadecapeptide corresponding to residues 176-191 of human growth hormone, with a tyrosine substitution at the N-terminus and an intramolecular disulfide bridge (Cys7-Cys14)