Carboxypeptidase enzymes degrade unprotected GHK within hours of topical application, which is why encapsulation and formulation pH matter as much as concentration
The broader copper peptide network The paper also notes that copper peptide complexes (including the related GHK-Cu) are known to increase VEGF (vascular endothelial growth factor) production and decrease TGF-1 secretion by dermal fibroblasts
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J Agric Food Chem 61(18):43524359 Achari C, Reddy GV, Reddy TCM, Reddanna P (2011) Chebulagic acid synergizes the cytotoxicity of doxorubicin in human hepatocellular carcinoma through COX-2 dependant modulation of MDR-1
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When oxidative stress is left unchecked, it can lead to the formation of harmful substances that damage blood vessels, contributing to conditions like atherosclerosis and high blood pressure
