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Blue pigmentation occurs in some lesions due to dermal melanophages

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However, due to the limited number of countries in which studies have been performed, exact interpretation of this issue must be with precaution

[6] Because systemic absorption of topically applied GHK-Cu seems minimal, clinically significant pharmacokinetic interactions with oral medications are unlikely

Researchers also examined major adverse CV events in patient subgroups on the basis of major adverse CV event rates in the placebo group, the presence or absence of CVD, HbA1c level, trial duration, treatment dosing interval, structural homology to human GLP-1 or exendin-4, BMI, age and eGFR