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OPs down-regulate the expression and the activity of several cholinergic components such as nicotinic and muscarinic cholinergic receptors (nAChR, mAChR), Choline acetyltransferase (ChAT), Acetylcholinesterase, butyrylcholinesterase and vesicular ACh transporter (AChE, BChE, and VAChT), thus leading to increased pro-inflammatory and decrease anti-inflammatory cytokines production