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However, only body weight improved significantly in the obese group

(2012) Lipid effects of peroxisome proliferator-activated receptor- agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome

The decision to escalate should be based on weight loss trajectory, appetite control , and side effect profile

Adding orlistat when already consuming less fat may provide minimal additional benefit, while still carrying orlistat's digestive side effects

The absence of documented adverse events reflects the absence of studies, not proven safety

Each meal should include protein, fibre-rich carbohydrates, and healthy fats