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Although the reaction of PhSeBr and 1a generating the SeN intermediate INT1-Se is endothermic by 12.6 kcal mol 1 , INT1-Se may readily undergo a Se-centred [2,3]-sigmatropic rearrangement to generate an ortho -Se = N substituted dearomatized species ( INT2-Se ) via TS1-Se , with a barrier of 12.7 kcal mol 1

Anxiety, depression and other negative emotions will increase the risk of MASLD (381)

It is an oxidized version of the drug vinblastine

Scoring criteria were as follows: score 0, no hair regrowth observed