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While glucagon traditionally raises blood glucose, the concurrent GLP-1 and GIP agonism counterbalances this hyperglycemic effect, allowing retatrutide to achieve net glycemic improvement while harnessing glucagon's catabolic benefits for energy expenditure and liver fat clearance

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10.1038/jid.2014.371 Ann

In simple terms, patients are not choosing between two options that are both available now

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The KFF data showed 54% of adults who had used GLP-1 drugs said it was difficult to afford them and 22% of that group described it as very difficult