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In this paper we draw from human electronic medical records, rodent behavioral studies, and single cell RNA sequencing to uncover a role for endogenous sex hormone signaling in mediating the differences in efficacy and tolerability between sexes that are observed with GLP1R agonists

The rare kidney complications those trials did record were acute kidney injury in people with severe dehydration or pre-existing renal disease

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GLP-1 agonists can be used longer-term and provide metabolic benefits beyond appetite reduction, including improved blood sugar control and cardiovascular outcomes in some populations

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