Lister R, Ecker JR (2009)
mtDNA activates cGAS signaling and suppresses the YAP-mediated endothelial cell proliferation program to promote inflammatory injury
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Beyond pharmacokinetic and methodological constraints, regulatory barriers further impede the clinical translation of natural compounds for AD therapy
Figure 3 3.3 Socioeconomic and health system impact PD imposes a significant socioeconomic burden, including direct healthcare costs (e.g., medications, hospitalizations, and surgery) and indirect costs (e.g., lost income, caregiver absenteeism, and reduced productivity)
Tolerance to selenoprotein loss differs between human and mouse