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While research has not definitively shown that creatine worsens kidney function in healthy individuals, data in those with established kidney disease remain limited

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However, the heterogeneity in treatment protocols, such as formulation and dosage of omega-3s used, suggests the need for standardized recommendations in clinical practice [168,169,170,171,172,173,174,175,176,177,178,179]

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The 2010 Buie consensus paper specifically called for endoscopic evaluation in children with autism and persistent GI symptoms, and any pediatric gastroenterologist should be willing to include disaccharidase testing in the workup