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Review total copper exposure from all sources

When unfolded or incorrectly folded proteins are present in the cell, ERS is activated to diminish the concentration of these abnormal proteins and prevent their aggregation

Oxidized low-density lipids (O-LDL) have been associated with an increased risk of cardiovascular disease and have been shown to induce endothelial cell damage

doi: 10.1158/1535-7163.MCT-08-0625

But if you're low on these two amino acids, then you may need to take a cysteine supplement

Adequate hydration (at least 2-3 liters daily), fiber supplementation, and magnesium citrate at bedtime are the first-line approaches