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About 9 million Americans were taking a GLP-1 drug as of the end of 2022, a Trilliant Health analysis found

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The molecule makes three changes to the native hormone fragment: a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, inversion to D-phenylalanine at position 7, and substitution of norleucine for the oxidation-prone methionine at position 4

[238] The 10 mg dose is particularly likely to cause significant drowsiness that may impair reaction time, concentration, and motor coordination